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At meeting on guardrails for gene editing of human embryos, some call for a dead end

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At meeting on human embryo editing, CRISPR pioneer says science is a long way from knowing if germline DNA can be safely altered.
The article from STAT News discusses the ongoing concerns and ethical debates surrounding germline gene editing in human embryos. Scientists are grappling with the safety and efficacy of these techniques, particularly after a study highlighted significant issues with mosaicism, where edited genes do not uniformly affect all cells in an embryo. This leads to potential health risks for any resulting offspring. The study, published in a notable scientific journal, found that even with advanced CRISPR technology, unintended genetic changes and off-target effects were common, raising alarms about the long-term implications of such edits. Ethical considerations are also prominent, with many in the scientific community advocating for a moratorium on clinical applications until more is understood about the safety and the long-term effects. The piece also touches on the regulatory landscape, where different countries have varying stances on the permissibility of germline editing, and the urgent call for international guidelines to manage this powerful technology responsibly.

Read the Full STAT Article at:
[ https://www.statnews.com/2025/03/28/human-embryo-germline-gene-editing-safety-troubles-scientists/ ]