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New "Molecular GPS" Allows Immune Cells To Kill Brain Cancer Without Harming Healthy Tissue

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          🞛 This publication is a summary or evaluation of another publication 🞛 This publication contains editorial commentary or bias from the source
Researchers have developed a method to program immune cells to target glioblastoma and reduce inflammation associated with multiple sclerosis in mice. This technology is set to undergo clinical trials in humans for glioblastoma treatment.
The article from SciTechDaily discusses a groundbreaking development in cancer treatment where researchers have engineered a new molecular "GPS" system to guide immune cells specifically to brain cancer cells, sparing healthy brain tissue. This innovative approach utilizes CAR T-cell therapy, where T cells are genetically modified to express chimeric antigen receptors (CARs) that target specific proteins on cancer cells. The key advancement is the use of a molecule called synNotch, which acts like a molecular switch, activating only when it binds to a specific antigen on cancer cells. This activation then triggers the expression of another CAR that targets a second antigen, ensuring that the T cells attack only the cancer cells. This dual-targeting strategy significantly reduces the risk of off-target effects, a common issue in previous CAR T-cell therapies where healthy cells could also be attacked. The study, published in Nature Communications, demonstrates this method's potential in treating glioblastoma, one of the most aggressive and hard-to-treat brain cancers, by effectively killing tumor cells while leaving normal brain tissue unharmed.

Read the Full SciTech Daily Article at:
[ https://scitechdaily.com/new-molecular-gps-allows-immune-cells-to-kill-brain-cancer-without-harming-healthy-tissue/ ]